Delivery of nucleic acids for cancer gene therapy: overcoming extra- and intra-cellular barriers
نویسندگان
چکیده
منابع مشابه
Non-biological gene carriers designed for overcoming the major extra- and intracellular hurdles in gene delivery, an updated review
Gene therapy as a modern therapeutic approach has not yet advanced to a globally-approved therapeutic approach. Lack of adequate reliable gene delivery system seems to be one of the major reasons from the pharmaceutical biotechnology point of view. Main obstacles delaying successful application of human gene therapy are presented in this review. The unique advantages of non-biological gene carr...
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Background Nucleic acids are emerging as a novel class of therapeutics for cancer treatment. For example, RNA interference (RNAi)based gene silencing has been widely used for identification and validation of putative cancer targets, and several RNAi nanotherapeutics are now under clinical trials in cancer patients. Messenger RNA (mRNA) has also shown unique advantages for the development of can...
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Most solid tumors are of epithelial origin and, although malignant cells are de-differentiated, they maintain intercellular junctions, a key feature of epithelial cells, both in the primary tumor as well as in metastatic lesions. These intercellular junctions represent a protective mechanism against attacks by the host's immune system and pose as physical barriers that prevent intratumoral pene...
متن کاملNucleic Acids in Gene Delivery and Gene Regulation
The concept of gene therapy, initially attributed to a technology that would allow the correction of inherited genetic disease, has evolved over the years. The realization of the immense technical hurdles to achieve genetic correction led to a broadening of the concept now including the transfer of genetic material whose expression will counteract, mitigate or revert a disease phenotype. This c...
متن کاملnon-biological gene carriers designed for overcoming the major extra- and intracellular hurdles in gene delivery, an updated review
gene therapy as a modern therapeutic approach has not yet advanced to a globally-approved therapeutic approach. lack of adequate reliable gene delivery system seems to be one of the major reasons from the pharmaceutical biotechnology point of view. main obstacles delaying successful application of human gene therapy are presented in this review. the unique advantages of non-biological gene carr...
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ژورنال
عنوان ژورنال: Therapeutic Delivery
سال: 2016
ISSN: 2041-5990,2041-6008
DOI: 10.4155/tde-2016-0049